Scientists closer to freezing human organs - FOX 35 News Orlando

Scientists closer to freezing human organs

Posted: Updated:
Health News Health News
By FOX NEWS -

In order to preserve biological materials over an extended period of time, doctors rely on a process known as cryopreservation – a procedure that involves cooling human tissues to sub-zero temperatures. This frozen state effectively blocks chemical reactions from occurring and causing any damage to the materials, allowing them to remain viable for medical use later on.

However, cryopreservation is a risky process and is often reserved for the conservation of smaller groups of tissues or individual cells – such as embryos and stem cells. Freezing larger biological tissues is much more difficult. These materials often contain large amounts of water, which form ice crystals when frozen, causing significant damage to the cells and tissue.

But now, freezing larger amounts of human tissue may soon become a feasible option. Researchers from Villanova University have discovered how ice crystals invade and damage biological material during the freezing process – a significant discovery that could lead to new methods of preventing tissue injury during cryopreservation.

By overcoming this obstacle, freezing complex human tissues such as full-sized donor organs or artificially engineered replacement tissues could be a very real option for physicians.

“If you can cryopreserve tissue or even organs, then you have a way of storing them and of transporting them,” senior author Dr. Jens Karlsson, of the department of mechanical engineering at Villanova University, told FoxNews.com. “Now if you want to do a (lung) transplantation, you’re rushing the harvest organ from one hospital to another by helicopter, and you only have a few hours to do it. But if you’re able to preserve the tissue, then you have as much time as you want and you can really find the best match for the tissue and transport it over much longer distances.”

To better understand how ice interacts with cells as they freeze, Karlsson and his team utilized a video cryomicroscrope, which allowed them to observe the freezing process using high-speed imaging.

“We could record what happens and play it back in slow motion and really see in great detail what the interactions are between the ice, and cells in the tissue,” Karlsson said.

With this microscope, the team monitored the freezing events of genetically modified cells, some of which contained certain junction proteins and some of which did not. These junction proteins either suppressed or encouraged the formation of the cells’ gap junctions and tight junctions– channels that connect adjacent cells together. Gap junctions directly connect the cytoplasm of two cells, while tight junctions provide an even closer connection by firmly stitching together the cells’ plasma membranes.

The researchers found that when the gap junctions were suppressed in the cells, the ice still spread freely throughout the tissue. This meant that the extremely snug tight junctions played a significant role in allowing the ice to infiltrate the cells.

Read more at Fox News


  • Local NewsLocal NewsMore>>

  • 3 NJ mayors to announce anti-crime plan

    3 NJ mayors to announce anti-crime plan

    Monday, July 28 2014 9:03 AM EDT2014-07-28 13:03:29 GMT
    The mayors of three of New Jersey's largest cities are announcing a joint initiative to combat violent crime. Newark Mayor Ras Baraka, Jersey City Mayor Steven Fulop and Paterson Mayor Jose Torres have scheduled a news conference in Jersey City for Monday afternoon to announce the plan. The news conference is being held in one of Jersey City's most crime-plagued neighborhoods.
    The mayors of three of New Jersey's largest cities are announcing a joint initiative to combat violent crime. Newark Mayor Ras Baraka, Jersey City Mayor Steven Fulop and Paterson Mayor Jose Torres have scheduled a news conference in Jersey City for Monday afternoon to announce the plan. The news conference is being held in one of Jersey City's most crime-plagued neighborhoods.
  • Man charged with shooting pet turtle

    Man charged with shooting pet turtle

    Monday, July 28 2014 8:26 AM EDT2014-07-28 12:26:19 GMT
    A Stonington man has been charged with cruelty to animals after police say he shot his girlfriend's pet turtle. Steven Richard, 31, reportedly used a BB gun to shoot the turtle in the head Friday night outside a home on Pawtucket Avenue. Police responded to the home just after 8 p.m. when a neighbor reported an argument between Richard and the woman who lives there.
    A Stonington man has been charged with cruelty to animals after police say he shot his girlfriend's pet turtle. Steven Richard, 31, reportedly used a BB gun to shoot the turtle in the head Friday night outside a home on Pawtucket Avenue. Police responded to the home just after 8 p.m. when a neighbor reported an argument between Richard and the woman who lives there.
  • Man dies trapped in elevator shaft

    Man dies trapped in elevator shaft

    Monday, July 28 2014 8:06 AM EDT2014-07-28 12:06:40 GMT
    New York City NewsNew York City News
    A man died after becoming trapped between an elevator shaft and elevator car in the Bronx, said police. Police were called to 680 Tinton Ave. in The Bronx at about 3:55 a.m. on Monday. The man was found unconscious between the 18th and 19th floors. It is not clear how the man became trapped. A police investigation was underway. The medical examiner will determine the cause of death.
    A man died after becoming trapped between an elevator shaft and elevator car in the Bronx, said police. Police were called to 680 Tinton Ave. in The Bronx at about 3:55 a.m. on Monday. The man was found unconscious between the 18th and 19th floors. It is not clear how the man became trapped. A police investigation was underway. The medical examiner will determine the cause of death.
Powered by WorldNow

35 Skyline Drive
Lake Mary, FL 32746

Phone: (407) 644-3535
News Tips: (866) 55-FOX35

Didn't find what you were looking for?
All content © Copyright 2000 - 2014 Fox Television Stations, Inc. and Worldnow. All Rights Reserved.
Privacy Policy | Terms of Service | Ad Choices