A Freeze Warning is in effect for Marion, Putnam, and Alachua counties while a Frost Advisory is in effect for Flagler and Sumter counties, where patchy frost is likely.
"Expect clear and cold weather overnight with temperatures dropping into the lower 40s for most of Central Florida. Warming begins Friday and continues into next week, when daily highs will hit around 80," said FOX 35/FOX 51 Chief Meteorologist Glenn Richards.
The blast of colder air comes a day after a winter storm dumped snow and ice in the Deep South, which prompted cancellations of thousands of flights, led to mass power outages and contributed to hundreds of crashes on roadways in Alabama, Georgia and the Carolinas.
That same system is now wreaking similar havoc along the East Coast.
Baltimore awoke to 15 inches of snow Thursday, and Philadelphia had nearly 9 inches, making it the fourth 6-inch snowstorm of the season for that city.
At least 17 deaths were blamed on the storm that has created hazardous commuting conditions. In New York, a 36-year-old pregnant woman was struck by a plow and killed, the NYPD confirmed to Fox News. Authorities rushed her to a hospital in Brooklyn where staff are attending to the unborn child.
The procession of storms and cold blasts are blamed, in part, on a kink in the jet stream.
Some information taken from FoxNews.com and the Associated Press.